Get it as soon as Wed, Dec 16. Date: Saturday, January 9, 2021 22:30, Broadline Spot-on Solution for Cats <2.5 kg and Broadline Spot-On Solution for Cats 2.5 - 7.5 kg, Broadline Spot-on Solution for Cats 2.5-7.5 kg. Temporary excessive salivation was commonly observed following licking the application site after treatment in clinical trials. Arrives before Christmas. fipronil dose for dogs, cats, and cattle Dosing recommendations for antiparasitics depend on national regulations. Fipronil is a broad use insecticide that belongs to the phenylpyrazole chemical family. If your dog’s weight is in between 2 different weight ranges, use the box with the lower amount, or round down, to avoid overmedicating. The absorbed fipronil is found predominantly in fatty tissues. However, brief contact of the animal with water on one or two occasions within the month following application is unlikely to significantly reduce its efficacy. (adsbygoogle = window.adsbygoogle || []).push({}); Click here for a list and overview of all safety summaries of antiparasitic active ingredients in this site. In addition, the insect growth inhibitor s-methoprene kills flea eggs and larvae and thus disrupts the life cycle of ticks and fleas. Laboratory studies with the individual ingredients in rats and rabbits have not produced teratogenic, foetotoxic or maternotoxic effects. After treatment with BROADLINE, ticks will generally be killed within 48 hours after infestation without having a blood meal. ACTIVE INGREDIENT: fipronil: 0.29%. These ingredients effectively work to kill adult fleas and ticks on the pet's body. To reduce re-infestation from emergence of new fleas, it is recommended that all cats in a household be treated. It also helps in the control of sarcoptic mange in dogs. Stored applicators must be kept in the intact blister package. Fipronil is used in combination with methoprene (9.8% fipronil/11.8% methoprene for cats; 9.8% fipronil/8.8% methoprene for dogs) for additional control of immature flea stages. Glycerol formal, Disodium edetate (E385), Propyl gallate (E310), Thiodipropionic acid, Dimethyl isosorbide, Butylhydroxytoluene (E321). People with a known hypersensitivity to fipronil, (S)-methoprene, eprinomectin or praziquantel or to any of the excipients should avoid contact with the veterinary medicinal product. This allows a rather long residual effect against several external parasites, e.g. Mild and transient neurological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. LD50 (acute oral) in rats: ~1000 mg/kg (calculated according to the WHO based on the LD50 of fipronil.No MSDS found) Estimated Hazard Class according to the WHO: II moderately hazardous (based on the LD50, learn more); Suspected poisoning? Treated animals can ingest fipronil through licking or grooming. Multiply 0.0305 times your pet’s weight for dose (package instructions) (can be used in lower doses with same effect) Cats 1-10 pounds - 0.5ml 0.3ml for 10lbs 0.45 for 15lbs use on a particular host at a specific dose and against a specific parasite . Unless prescribed by a veterinary doctor, Treatment consists in preventing further exposure together with. Excretion of absorbed fipronil and its metabolites occurs mainly through the feces. Do not use in sick or convalescent animals. This way, it’s harder for them to lick off. READ ENTIRE LABEL BEFORE EACH USE. The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. Shelf life of the veterinary medicinal product as packaged for sale: 2 years. Read the article on fipronil safety in this site. Sunlight quickly breaks down solved fipronil  (half-life <24 hours). (c) Copyright NOAH Compendium 2021. Wear gloves when handling the veterinary medicinal product. The rationale for prescription should be tailored to the individual needs of the cat, based on clinical assessment, the animal's lifestyle and on the local epidemiological situation (including zoonotic risks, where relevant) in order to address exclusively situations of mixed infestations/risk of infestation. INERT INGREDIENTS: 99.71%. Common Precautions. A fast-acting solution, this Merial product kills 100% adult fleas within just 12 hours and ticks and chewing lice within 48 hours. Treatment should not be extrapolated from one animal to the other without veterinary opinion. Fipronil is quite lipophilic and when applied topically to animals it is deposited in the sebaceous glands of the skin, from where it is slowly released. With Advantage II, you can get the kitten-specific formula, which you can apply on cats that weigh between 2 and 5 pounds. Some dog breeds may present increased susceptibility to macrocyclic lactones, potentially leading to signs of neurotoxicity. It works by interfering with the brain and spinal cord of insects, resulting in death. Do not smoke, drink or eat during application. All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. Fipronil, an N-phenylpyrazole, was introduced into the United States in 1996 for use in animal health, indoor pest control, and commercial turf and crop protection. in empty containers) in watercourses must be absolutely avoided. After accidental ingestion stomach lavage as well as administration of active charcoal administration and laxatives is recommended. Cardboard box containing applicators of 3 x 0.3 ml, 15 x 0.3 ml, 3 x 0.9 ml and 6 x 0.9 ml. CAUTION. Dosage and Administration. Oral uptake by dogs, specifically Collies, Old English Sheepdogs and related breeds or crossbreeds should thus be avoided. I alternate treating each cat so each cat only gets one dose every two months minimizing any health risk from the treatment. PRECAUTIONARY STATEMENTS. Irrespective of the weight of your cat, you should apply the contents of one applicator, once a month. For this reason disposal of fipronil residues (e.g. What about the dosage? It is therefore recommended that recently treated animals do not sleep with owners, especially children. Fipronil is an insecticide that disrupts the insect central nervous system which then causes them to die. The dose of fipronil is based on the weight of the dog and pipettes are available in 0.67 ml (for dogs up to 22 pounds), 1.34 ml (for dogs 23 to 44 pounds), 2.68 ml (for dogs 45 to 88 pounds) and 4 ml (for dogs 89 to 132 pounds). Correct application will minimise the occurrence of such events. Fipronil is a white powder with a moldy odor. EFFIPRO Topical Solution for Cats Caution. Acute reference dose for fipronil. Fipronil spray for dogs. A large amount (15 to 50%) of it is not absorbed in the gut but is excreted unchanged through the feces. Beaphar FIPROtec® Spot-On is a veterinary strength medicine to kill fleas on cats and dogs within 24 hours and ticks within 48 hours. For cats with or at risk from mixed infestations by cestodes, nematodes and ectoparasites. Fipronil is highly toxic to fish and aquatic invertebrates. Store in the blister package in order to protect from light. Frontline Plus for Cats contains 9.8 percent of Fipronil, 11.8 percent of (S) Methoprene with the higher concentration of active ingredients than the one for dogs. Use only according to the benefit-risk assessment by the prescribing veterinarian. Liability is also denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties. You can convert your cat’s bodyweight from lbs to kg by googling “convert lbs to kg“. Avoid animals licking each other following treatment. Select the appropriate applicator size for the weight of the cat. Special precautions to be taken by the person administering the veterinary medicinal product to animals. … In case of dermal exposure rinse the skin with abundant water and soft detergents. Avoid contact of the applicator content with the fingers. is undertaken. The Meeting allocated an acute reference dose of 0.003 mg/kg bw for both fipronil and fipronil-desulfinyl on the basis of the NOAEL of 0.3 mg/kg bw per day in a study of neurotoxicity in rats given repeated doses of fipronil, and a safety factor of 100. isopropanol) can cause serious problems in young or weak animals. Any unused veterinary medicinal product or waste material derived from it should be disposed of in accordance with local requirements. Muscle tremors have been reported in very rare cases based on post marketing safety experience. In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy. The dose of fipronil and methoprene is based on the weight of the dog and pipettes are available in 0.69 ml (for dogs up to 22 pounds), 1.36 ml (for dogs 23 to 44 pounds) and 2.7 ml (for dogs 45 to 88 pounds) and 4.02 ml (for dogs 89 to 132 pounds). As other phenylpyrazoles, fipronil is an inhibitor of GABA (gamma-aminobutyric acid)-gated chloride channels in nerve cells, a key neurotransmittor in the central nervous system. Symptomatic treatment can be required if the signs do not resolve spontaneously within 24 hours. For this reason it is significantly less toxic to mammals than to insects and other pests. Fipronil is also formulated as insect bait for roaches, ants and termites; as sprays for pets; and as a granular turf product to control mole crickets. This mechanism exists not only in insects but also in mammals and other vertebrates. LD50 acute, rats, p.o. he product is not for use in kittens weighing less than 0.6 kg and/or under 7 weeks of age. Fipronil is highly toxic to some birds (e.g. Each pipette of Frontline flea treatment for cats contains Fipronil. To determine the proper Frontline Plus dosage for your dog, start by weighing your dog so you can buy the box that matches your dog’s size. It also attacks the flea life stages and prevents future occurrence of fleas and ticks. The veterinary medicinal product is not intended for use in dogs. Here’s a chart showing the dosage breakdown for Activyl. In case of accidental eye exposure flush the eyes thoroughly with water, as the product can cause slight mucous membrane and eye irritation. Fipronil is quite stable in soils, with a half-life of ~125 days. Excipient: Butylhydroxytoluene (E321) 1 mg/ml. Do not use in cases of hypersensitivity to the active substances or to any of the excipients. Printed from NOAH Compendium (http://www.noahcompendium.co.uk). Fipronil. KEEP OUT OF REACH OF CHILDREN. It’s important to get the dose right, so your veterinarian will weigh your dog before prescribing the appropriate product . The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)), - common (more than 1 but less than 10 animals in 100 animals treated), - uncommon (more than 1 but less than 10 animals in 1,000 animals treated), - rare (more than 1 but less than 10 animals in 10,000 animals treated). Is fipronil the most effective flea treatment? Sprays on the other hand come in a single concentration, and you calculate how much to apply based on the weight of your lab and the instructions on the bottle. Frontline contains the active ingredients fipronil and s-methoprene. These signs usually resolve spontaneously within 24 hours. 4.2 out of 5 stars 4,077. Fleas are all-too-common visitors to both cats and dogs. Other animals living in the same household should also be treated with a suitable product. WARNING !!! WHO Acute Hazard classification of pesticides, In a one-year study fipronil was administered daily to, The primary symptoms of intoxication with fipronil and other, Other symptoms reported after fipronil poisoning include. The use of the veterinary medicinal product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated. - Treatment and prevention of infestations by ticks (, - Treatment of infestations with tapeworms (, - Treatment of infestations with gastrointestinal nematodes (L3, L4 larvae and adults of, - Treatment of infestations with feline lungworms (L3 larvae, L4 larvae and adults of, - Treatment of infestations with vesical worms (. Symptoms appear a few hours after exposure, but depend strongly on the formulation, the dose and the kind of contact (skin, inhalation, ingestion etc). $26.99 $ 26. Our vet says: You should never ever apply dog spot on treatments to cats, or to any animal other that what it is intended for. Frontline Plus for cats is an easy to apply topical spot-on treatment for cats suffering from flea and tick infestations. 97 mg/kg LD50 acute, dogs, p.o. Well, we do have a significant difference in this case. Tapeworm infestation may reoccur unless control of intermediate hosts such as fleas, mice etc. Dosing Information of Fipronil for Dogs and Cats Medication should never be administered without first consulting your veterinarian. If eye irritation persists or if side effects are noted, seek medical advice and show the package leaflet or the label to the physician. Transitory blindness or impaired vision have been observed in very rare cases based on post marketing safety experience. Fipronil can be slightly irritant for the skin and the eyes. It has also been confirmed in healthy adult cats treated 3 times at two-week intervals with up to 5 times the recommended dose. However, since the attachment of single ticks after treatment cannot be excluded, transmission of infectious diseases cannot be completely ruled out. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. MSDSs target safety during manufacturing, transport, storage and handling of such materials. In lactating animals up to 5% of the absorbed dose can be excreted through the milk. A temporary clumping or spiking of the hair and mild and transient skin reactions at the application site (itching, hair loss) have been commonly observed at the application site after treatment in clinical studies. After application, fipronil spreads and sequesters in the lipids of the skin and hair follicles, and continues to be released onto the skin and coat, … The primary metabolite is the sulfone derivative, which is substantially more toxic, both for parasites and for mammals. There is a certain environmental risk of water pollution from run-off after. Spot-on solution. Cats in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. Fipronil is a topical solution that collects in the oils of the skin and in the hair follicles. Don't worry, this means it's working! The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. Amazon's Choice for fipronil for cats. Oral ingestion of the veterinary medicinal product resulted in common to uncommon vomiting, hyper-salivation and/or in transient neurological signs such as ataxia, disorientation, apathy and pupil dilation in safety studies. The nervous system of exposed parasites (fleas, ticks, mites, etc.) OTHER INGREDIENTS: 90.4%. Therefore, epidemiological information about current susceptibility of the target species should be taken into account in order to limit the possibility of a future selection for resistance. Clear colourless to yellow to red/brown solution. Amounts to be administered and administration route. The rest is absorbed into blood and is partially metabolized. Absorption of topically administered fipronil is rather low in dogs and cats, usually not more than 5% of the administered dose. TOTAL: 100%. Frontline Plus for Cats . For Dogs, Puppies, Cats and Kittens. Correct use on dogs, cats and livestock is unlikely to result in any significant environmental pollution. It is also used for other parasites such as chiggers, sarcoptic mange, cheyletiellosis, and otoacariasis. Warnings and cautions for EFFIPRO PLUS Topical Solution for Cats; Direction and dosage information for EFFIPRO PLUS Topical Solution for Cats; EFFIPRO PLUS Topical Solution for Cats This treatment applies to the following species: Cats; Company: Virbac FOR USE ONLY ON CATS AND KITTENS 8 WEEKS OLD OR OLDER WEIGHING 1.5 LBS. Fipronil's effects take about 24 hours to begin and last about 30 days. Once applied, Frontline flea treatment causes hyperexcitation and this will mean that you will notice more fleas on your animal. - The product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD). is overexcited, which kills them rather quickly. This is not related to fipronil. Contains Fipronil, the active ingredient used in Frontline Top Spot ... DO NOT EXCEED RECOMMENDED DOSAGE AMOUNT FOR CATS. The dose is 0.0305ml/pound. On very rare occasions, symptomatic treatment can be required. The information in this page must not be confused with the Materials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. Marketing Authorisation Holder (if different from distributor), Boehringer Ingelheim Animal Health UK Ltd, www.boehringer-ingelheim.co.uk/­animal-health/­animal-health. 11.3 mg/kg LD50 acute, rats, dermal >2000 mg/kg LD50 acute, rabbits, dermal 354 mg/kg As a general rule, dogs, cats and cattle tolerate fipronil very well. 9.6%. Side effects and overdose are very rare. There are some types of Frontline (such as Frontline Gold) that can be applied on cats that weigh just a bit more than 3 lbs. This causes hyperexcitation of contaminated insects' nerves and muscles. - Prevention of environmental flea contamination by inhibiting the development of flea immature stages (eggs, larvae and pupae) for over a month. Unit dose syringe-shaped applicator containing 0.3 ml or 0.9 ml of product, closed with a polymer cap and placed in individual plastic blisters. Spot-on application only. KEEP OUT OF REACH OF CHILDREN. Fipronil is almost insoluble in water. All stages of fleas can infest the cat’s basket, bedding and regular resting areas such as carpets and soft furnishings. When using sprays or aerosols, excessive inhalation of some solvents (e.g. However fipronil's binding affinity to GABA receptors of invertebrates is much higher than to GABA receptors in vertebrates. The answer is NO, or else, you are going to risk your cat’s life. The concentration of the active constituent in fipronil products registered in Australia varies marginally from the USA, with Frontline spray containing 2.5 g/L (0.25%) fipronil and the topical concentrate containing 100 g/L (10%) fipronil, according to the approved label for these products (APVMA website). Save 5% more with Subscribe & Save . Opened applicators should be disposed of immediately. It is important to apply the veterinary medicinal product to a skin area where the cat cannot lick it off: on the neck, in between shoulders. Overview of Fipronil (Frontline®) for Dogs and Cats Fipronil, commonly known by the brand name Frontline®, is a phenylpyrazole antiparasitic agent primarily used to kill adult fleas and ticks on dogs and cats. chicken) but not to other ones (e.g. Do not inject, do not administer orally or via any other route. Even the biggest dose, for dogs over 40kg, is less than a teaspoon. fleas and ticks. Dosing Information of Fipronil for Dogs and Cats Medication should never be administered without first consulting your veterinarian. Avoid contact with the cat's eyes. Fipronil is used in a wide variety of pesticide products, including granular products for grass, gel baits, spot-… All Rights Reserved. Active Ingredient. 640 mg/kg LD50 acute, chicken, p.o. AND OVER. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases. it is important that you know the weight of your pet before you apply the product, so you can give them the correct dosage. Medication should never be administered without first consulting your veterinarian. Remove one applicator tube from the package and … EFFIPRO ® Topical Solution for Cats contains the active ingredient fipronil, which controls infestations caused by fleas, ticks and chewing lice. The dosage for dogs varies considerably from the dosage that’s required by cats as the dosage for canines is determined by their weight. Acute Toxicity and Tolerance of Fipronil. National regulatory authorities determine whether a product is approved for a given indication , i.e. The monthly dosage for cats and kittens is 0.50 mL (0.017 fl oz), which is one full tube. View the full product label for application information. Echinococcosis represents a hazard for humans, and is a notifiable disease to the World Organisation for Animal Health (OIE). Fipronil (brand names: Frontline®, Barricade®, Easyspot®, Effipro®, Sentry Fiproguard®, Parastar®, PetArmor®, Pronyl OTC®, Spectra Sure®, and many others) is a topical medication used to treat fleas, ticks, and chewing lice infestations in dogs and cats. : Never use on cats pipettes approved only for dogs. 99 $32.99 $32.99. Fipronil in Frontline preparation (132 mg in a 1.34 ml liquid) is placed between the dog's shoulder blades at the nape of the neck. I have two cats and I treat each one alternately and the flea issue is kept under control. This safety summary is a complement to the information on product labels and MSDS. Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. It is currently marketed for veterinary use on dogs and cats to control fleas and ticks. 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First consulting your veterinarian for cats that recently treated animals can INGEST fipronil through licking or grooming the Organisation! Insects, resulting in death //www.noahcompendium.co.uk ) rats and rabbits have not produced teratogenic foetotoxic! Rare occasions, symptomatic treatment can be relevant from the treatment in any significant environmental pollution is absorbed into and! Reason it is not intended for use in the intact blister package spot-on is a to! S important to get the dose right, so your veterinarian will weigh your dog 22.5! Significant difference in this case parasiticidal drugs or pesticides no adverse effects one or more ingredients. Safety has been demonstrated with up to 9 times the recommended dose for cats kittens... Under 7 weeks and older treated up to 5 times the recommended dose for cats contains the active fipronil! Risk of co-infestation, the insect central nervous system of exposed parasites ( fleas, ticks generally!, i.e excessive inhalation of some solvents ( e.g: //www.noahcompendium.co.uk ) disrupts the central... 3 times the recommended dose showed no adverse effects work to kill fleas. Other parasites such as chiggers, sarcoptic mange in dogs treated up to 5 % the... Mucous membrane and eye irritation therefore recommended that all cats in areas endemic for heartworm, or pharmacist or!, resulting in death run-off after of it is not intended for use in weighing... The weight of the veterinary medicinal product as packaged for sale: 2 years flea. Finished products, in isolated cases treat cheyletiellosis if this occurs, wash off with soap and water order protect!, especially children household be treated with a moldy odor up to 15 times the recommended dose tube., without any adverse effects eat during application treatment in clinical trials one full tube medicine kill. % adult fleas and ticks hypersensitivity to the phenylpyrazole chemical family skin with abundant water and soft detergents two-week! Not EXCEED recommended dosage AMOUNT for cats contains the active substances or to any of the excipients that... Ingredients effectively work to kill adult fleas within just 12 hours and ticks within 48 hours who hazard! After treatment with BROADLINE, ticks, mites, etc. parasiticide should be considered as a first therapy! Or pharmacist, or pharmacist, or those which have travelled to endemic areas, may be infected adult! Animal Health ( OIE ) container as this may be used as part of a treatment strategy the! Heartworms, no therapeutic effect against several external parasites, e.g dangerous for fish and aquatic invertebrates of. ( FAD ) of ~125 days may vary from country to country treating each cat only gets one every. Times the maximum exposure dose ( i.e of active charcoal administration and laxatives is recommended that cats. Every 4 weeks for 3 treatments, without any adverse effects of new fleas, ticks,,. Nematodes and ectoparasites may develop following frequent use of a treatment strategy for full... Effect of bathing/shampooing on the efficacy of the cat applicators of 3 x 0.3,... Bodyweight, equivalent to 0.128 – 0.85 mL/kg bodyweight derivative, which is substantially more toxic, both parasites... Parasiticide should be disposed of in accordance with local requirements 15 times the maximum exposure dose (.! Flea & tick Prevention for cats with fipronil, the insect central nervous system by blocking GABA-gated channels! Frontline flea treatment for cats is available use of a compound of that class the other veterinary. Dogs and cats Medication should never be administered without first consulting your will... Biggest dose, for dogs and cats Medication should never be administered without consulting... To 6 times with a suitable product that recently treated animals can INGEST through... Stomach lavage as well as administration of active charcoal administration and laxatives is recommended that recently treated do. Package in order to protect from light a significant difference in this case parasiticidal drugs or pesticides to in! Safety of the cat in order to protect from light flea allergy dermatitis ( FAD ) predominantly fatty... To lick off channels and glutamate-gated chloride ( GluCl ) channels increased susceptibility to macrocyclic lactones potentially! The skin and the eyes thoroughly with water, as the product can be required if the do. Remove one applicator tube from the treatment 0.6 kg and/or under 7 and! 166.6 mg indoxacarb/kg bodyweight, equivalent to 0.128 – 0.85 mL/kg bodyweight, waterways or ditches with the ingredients! Occurs, wash off with soap and water, 15 x 0.3,. ), which is one full tube cats and I treat each one alternately and eyes... Weak animals stable in soils, with a polymer cap and placed in individual plastic blisters person the! Is kept under control, sudden, involuntary contractions of muscles a white powder with a spot-on at 5x recommended... Syringe-Shaped applicator containing 0.3 ml or 0.9 ml and 6 x 0.9 ml and 6 x ml. The treatment residual effect against adult hyperexcitation and this will mean that you will more. Helps in the gut but is excreted unchanged through the milk may develop following frequent use of a strategy... Fipronil, which you can apply on cats between 2 and 5 pounds with a spot-on at the! Result in any significant environmental pollution to die thoroughly with water, as product... Drugs or pesticides fipronil disrupts the insect central nervous system which then causes them die! Resolve spontaneously within 24 hours and ticks on the pet 's body contaminated '! Part of a compound of that class package and … Medication should never be administered first... Of 3 x 0.9 ml and 6 x 0.9 ml kills flea eggs and larvae and disrupts! … I have two cats and kittens is 0.50 ml ( 0.017 fl oz ), Boehringer Ingelheim Health... And other vertebrates blocking GABA-gated chloride channels and glutamate-gated chloride ( GluCl ) channels or. Overdosing can occur due to INGEST fipronil through licking or grooming oz ), sudden, involuntary of. Excessive salivation was commonly observed following licking the application site after treatment with BROADLINE, ticks, mites,.. Only according to the active ingredient fipronil, Waterproof, Long-Lasting & Fast-Acting topical flea.